Anidulafungin is a useful surrogate marker for predicting <i>in vitro</i> susceptibility to rezafungin among five <i>Candida</i> species using CLSI methods and interpretive criteria.

ABSTRACT: This study addresses the use of other echinocandins as surrogate markers to predict the susceptibility of rezafungin against the six most common Candida spp. The Clinical Laboratory Standards Institute (CLSI) reference broth microdilution method was performed to test 5,720 clinical isolates of six different Candida species. Species-specific interpretative criteria by CLSI breakpoints or epidemiological cutoff values were applied. Essential agreement was 100% within two doubling dilutions for all species and comparisons. The categorical agreement of rezafungin using anidulafungin against all Candida spp. was 97.6% (2.9% very major errors [VMEs], 0.2% major errors [MEs], and 2.2% minor errors [miEs]); for caspofungin, it was 99.6% (11.4% VME, 0.09% ME, and 0.19% miE); an

SUBMITTER: Winkler ML 

PROVIDER: S-EPMC11837505 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature