A cytochrome <i>bd</i> repressed by a MarR family regulator confers resistance to metals, nitric oxide, sulfide, and cyanide in <i>Chromobacterium violaceum</i>.

ABSTRACT: Chromobacterium violaceum is a ubiquitous environmental pathogen. Despite its remarkable adaptability, little is known about the mechanisms of stress resistance in this bacterium. Here, in a screen for iron-susceptible transposon mutants, we identified a cytochrome bd that protects C. violaceum against multiple stresses. The two subunits of this cytochrome bd (CioAB) are encoded by the cioRAB operon, which also encodes a GbsR-type MarR family transcription factor (CioR). A ∆cioAB mutant strain was sensitive to iron and the iron-requiring antibiotic streptonigrin and showed a decrease in siderophore production. Growth curves and survival assays revealed that the ∆cioAB strain was also sensitive to zinc, hydrogen peroxide, nitric oxide, sulfid

SUBMITTER: Batista BB 

PROVIDER: S-EPMC11837568 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature