Evaluation of antimicrobial susceptibility testing methods for <i>Burkholderia cepacia</i> complex isolates from people with and without cystic fibrosis.

ABSTRACT: The Burkholderia cepacia complex (BCC) is a group of Gram-negative bacteria that cause opportunistic infections, most notably in people with cystic fibrosis (CF), and have been associated with outbreaks caused by contaminated medical products. Antimicrobial susceptibility testing (AST) is often used to guide treatment for BCC infections, perhaps most importantly in people with CF who are being considered for lung transplant. However, recent studies have highlighted problems with AST methods. Here, we address limitations from previous studies to further evaluate BCC AST methods. We assessed the performance of reference broth microdilution (BMD), disk diffusion (DD) using Mueller-Hinton agar (MHA) from three manufacturers, agar dilution (AD), and gradient diffusion (ETEST) for ceftazi

SUBMITTER: Jorth P 

PROVIDER: S-EPMC11837569 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature