Apelin-13 attenuates optic nerve damage in glaucomatous mice by regulating glucose metabolism.

ABSTRACT:

Background

In patients with advanced glaucoma, lesions frequently extend beyond the eye and affect other organs. However, early distal consequences of elevated intraocular pressure (IOP) remain unclear. This study aimed to observe glucose uptake in the optic cortex during the early stages of elevated IOP and to investigate the mechanism by which Apelin13 exerts neuroprotective effects.

Methods

This study used a single anterior chamber injection of polystyrene microbeads and triblock copolymer hydrogel in 6- to 8-week-old male C57BL/6J mice and observed glucose uptake in the optic cortex during the initial phase of IOP elevation using micro-positron emission tomography/magnetic resonance imaging (PET/MRI). Pathological changes in the optic nerve and optic cortex were assessed

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11837638 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature