Potential drug targets for ovarian cancer identified through Mendelian randomization and colocalization analysis.

ABSTRACT:

Background

The existing drugs for ovarian cancer (OC) are unsatisfactory and thus new drug targets are urgently required. We conducted proteome-wide Mendelian randomization (MR) and colocalization analysis to pinpoint potential targets for OC.

Methods

Data on protein quantitative trait loci (pQTL) for 734 plasma proteins were obtained from large genome-proteome-wide association studies. Genetic associations with OC were derived from the Ovarian Cancer Association Consortium, which included 25,509 cases and 40,941 controls. MR analysis was performed to evaluate the association between the proteins and the OC risk. Colocalization analysis was conducted to check whether the identified proteins and OC shared causal variants. In addition, the phenome-wide MR analysis was performe

SUBMITTER: Liu S 

PROVIDER: S-EPMC11837690 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature