The heterogeneity of T cell infiltration in human periapical lesions.

ABSTRACT:

Objectives

T lymphocytes (T cells) are crucial important types of immune cells which are responsible for adaptive immune response during the progression of bacterial infectious diseases. Different subtypes of T cells can participate in regulating the progress of human periapical lesions. This study investigates the co-localization of different types of T cells by multiplex immunofluorescence staining (mIHC) from different types of human periapical lesions (PLs) which might elucidate the potential clinical relevance of T cell infiltration with PLs.

Materials and methods

20 PLs tissues and 6 healthy samples from healthy periodontal ligament tissues were collected for subsequent experiments. Histological examination and immunohistochemical analysis were performed using hematoxy

SUBMITTER: Song Y 

PROVIDER: S-EPMC11837711 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature