Chromosomal and gonadal sex have differing effects on social motivation in mice.

ABSTRACT:

Background

Sex differences in brain development are thought to lead to sex variation in social behavior. Sex differences are fundamentally driven by both gonadal hormones and sex chromosomes, yet little is known about the independent effects of each on social behavior. Further, mouse models of the genetic liability for the neurodevelopmental disorder MYT1L Syndrome have shown sex-specific deficits in social motivation. In this study, we aimed to determine if gonadal hormones or sex chromosomes primarily mediate the sex differences seen in mouse social behavior, both at baseline and in the context of Myt1l haploinsufficiency.

Methods

Four-core genotypes (FCG) mice, which uncouple gonadal and chromosomal sex, were crossed with MYT1L heterozygous mice to create eight different

SUBMITTER: Chaturvedi SM 

PROVIDER: S-EPMC11837725 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature