Meaningful to whom? Minimal clinically important differences and the priorities of individuals living with dementia for everyday function.

ABSTRACT: Alzheimer's disease and Alzheimer's disease related dementias (AD/ADRD) have a significant impact on an individual's functional cognitive abilities, highlighting the need to prioritize measures of function in evaluating minimally clinically important difference (MCID) thresholds in AD/ADRD research. Input directly from individuals living with AD/ADRD on measures of function are lacking in MCID discussions, including what it means to live with AD/ADRD and what type and degree of improvements are most meaningful across the disease continuum. Most measures for assessing function in AD/ADRD trials are largely focused on basic and instrumental activities of daily living (BADL, IADL), which lack aspects of everyday function that matter most to individuals living with AD/ADRD. Expanding outcome e

SUBMITTER: Gilmore-Bykovskyi A 

PROVIDER: S-EPMC11837733 | biostudies-literature | 2025 Jan-Mar

REPOSITORIES: biostudies-literature