Design, synthesis and biological activity of peptidyl β-nitrostyrenes as cysteine protease inhibitors against <i>Leishmania donovani</i>.

ABSTRACT: Cysteine proteases are essential for the survival of Leishmania parasites that cause several clinical forms of leishmaniases. Inhibiting cysteine protease can be a promising strategy against parasitic diseases because of their essential functions in the life cycles of these pathogens. The aim of the present study was to synthesize and evaluate peptidyl -nitrostyrenes as antipromastigote inhibitors against Leishmania donovani promastigotes. A library of 12 peptidyl β-nitrostyrenes was synthesized and evaluated for anti-promastigote activity. Most of the compounds exhibited comparable activity to the standard, with IC₅₀ values ranging from 1.468 to 16.81 μM. Notably, compounds 14a, 14e, 14f, and 14g showed significant activity against both L. donovani promasti

SUBMITTER: Sharma S 

PROVIDER: S-EPMC11837772 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature