COVID-19 vaccination and birth outcomes of 186,990 women vaccinated before pregnancy: an England-wide cohort study.

ABSTRACT:

Background

COVID-19 vaccination in pregnancy is recommended by the World Health Organisation as effective and safe. However, there remains a lack of robust evidence to inform vaccination choices for women of childbearing potential in relation to their future pregnancies. Here we investigated the association between starting a course of COVID-19 vaccination before pregnancy and birth outcomes.

Methods

We analysed England-wide linked electronic health records for all pregnancies reaching at least 24 weeks gestation between 25th May 2021 and 28th October 2022. We estimated incidence rates and hazard ratios for birth and pregnancy outcomes by pre-pregnancy COVID-19 vaccination status.

Findings

Based on 186,990 women, compared to starting a pregnancy unvaccinated, receivin

SUBMITTER: Suseeladevi AK 

PROVIDER: S-EPMC11838104 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature