Single-Cell Multimodal Profiling Reveals a Novel CD26⁺ Fibroblast Subpopulation in Atherosclerosis.

ABSTRACT:

Background

Atherosclerosis involves complex interactions between lipids, immune cells, vascular smooth muscle cells (VSMCs), and fibroblasts within the arterial wall. While significant advances in single-cell technologies have shed light on the roles of immune cells and VSMCs in plaque development, fibroblasts remain underexplored, leaving critical gaps in understanding their contributions to disease progression and plaque stability. Comprehensive characterization of fibroblast phenotypes in atherosclerosis is essential to unravel their diverse functions and to distinguish between subsets that may play protective versus pathogenic roles in the disease process.

Methods

Here, we utilized CITE-seq (Cellular Indexing of Transcriptomes and Epitopes by Sequencing) to comprehensive

SUBMITTER: Bashore AC 

PROVIDER: S-EPMC11838260 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature