Acquisition of ampliconic sequences marks a selfish mouse t-haplotype.

ABSTRACT: Mendelian genetics posits equal transmission of alleles, but selfish alleles can bias the transmission of large genomic regions or entire chromosomes^1-4. One long-standing question is how transmission bias evolves to encompass large genomic regions. Mus musculus (house mouse) t-haplotypes exhibit up to 99% transmission bias from heterozygous males^5-14 and harbor selfish alleles^9-14 genetically linked to large inversions spanning the proximal half of chromosome 17^15-20. Here, by generating a high-quality, single-haplotype assembly of a t-haplotype, we reveal the evolution of eight large amplicons with known^11,13,21 and candidate selfish alleles as a distinct genetic feature. Three amplicons are conserved in closely

SUBMITTER: Swanepoel CM 

PROVIDER: S-EPMC11838278 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature