Multi-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish.

ABSTRACT: Aging is associated with progressive tissue dysfunction, leading to frailty and mortality. Characterizing aging features, such as changes in gene expression and dynamics, shared across tissues or specific to each tissue, is crucial for understanding systemic and local factors contributing to the aging process. We performed RNA-sequencing on 13 tissues at 6 different ages in the African turquoise killifish, the shortest-lived vertebrate that can be raised in captivity. This comprehensive, sex-balanced 'atlas' dataset reveals the varying strength of sex-age interactions across killifish tissues and identifies age-altered biological pathways that are evolutionarily conserved. Demonstrating the utility of this resource, we discovered that the killifish head kidney exhibits a myeloid bias durin

SUBMITTER: Costa EK 

PROVIDER: S-EPMC11838286 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature