Clonal relationships between Tph and Tfh cells in patients with SLE and in murine lupus.

ABSTRACT: Pathologic T cell-B cell interactions drive disease in systemic lupus erythematosus (SLE). The T cells that activate B cell responses include T peripheral helper (Tph) and T follicular helper (Tfh) cells, yet the developmental and clonal relationships between these B cell-helper T cell populations are unclear. Here we use T cell receptor (TCR) profiling to demonstrate clonal overlap between Tph and Tfh cells in the circulation of patients with SLE. Expanded Tph and Tfh cell clones persist over the course of 1 year in patients with a new diagnosis of SLE, and clones are observed to shift both from Tfh to Tph cells and from Tph to Tfh cells over time. High resolution analysis of cells sorted as Tph cells (CXCR5^- PD-1^hi) and Tfh cells (CXCR5⁺ PD-1^hi

SUBMITTER: Sasaki T 

PROVIDER: S-EPMC11838332 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature