Sequential oxidation of L-lysine by a non-heme iron hydroxylase.

ABSTRACT: 2-oxoglutarate-dependent non-heme iron hydroxylases offer a direct route to functionalizing C(sp3)-H bonds across a diverse range of substrates, making them prime candidates for chemoenzymatic synthetic strategies. We demonstrate the ability of a non-heme iron L-lysine dioxygenase to perform sequential oxidation and computationally explore structural elements that promote this reactivity.

SUBMITTER: Reynolds ES 

PROVIDER: S-EPMC11838370 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature