Anterior cingulate cortex in complex associative learning: monitoring action state and action content.

ABSTRACT: Environmental changes necessitate adaptive responses, and thus the ability to monitor one's actions and their connection to specific cues and outcomes is crucial for survival. The anterior cingulate cortex (ACC) is implicated in these processes, yet its precise role in action monitoring and outcome evaluation remains unclear. To investigate this, we developed a novel discrimination-avoidance task for mice, designed with clear temporal separation between actions and outcomes. Our findings show that ACC neurons primarily encode post-action variables over extended periods, reflecting the animal's preceding actions rather than the outcomes or values of those actions. Specifically, we identified two distinct subpopulations of ACC neurons: one encoding the action state (whether an action was tak

SUBMITTER: Huang W 

PROVIDER: S-EPMC11838375 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature