Early Life Outcomes of Prenatal Exposure to Alcohol and Synthetic Cannabinoids in Mice.

ABSTRACT: This study explores the effects of prenatal co-exposure to alcohol and synthetic cannabinoids on offspring viability, physical development, and neurobehavioral outcomes in young adulthood. The aim is to identify distinct outcomes of co-exposure compared to single-drug exposures and to examine potential sex-specific vulnerabilities in motor coordination and exploratory behaviors. Pregnant C57Bl/6J mice were assigned to one of four treatment groups: Control, Alcohol-exposed, Cannabinoid-exposed, or Alcohol+Cannabinoid-exposed, with drug administration occurring between Gestational Days 12-15. Offspring were first evaluated at birth for survival, physical malformations, and developmental delays. Subsequently, young adult offspring were assessed for motor coordination using rotarod tests and e

SUBMITTER: Rouzer SK 

PROVIDER: S-EPMC11838379 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature