WDR2 regulates the orphan kinesin KIN-G to promote hook complex and Golgi biogenesis in <i>Trypanosoma brucei</i>.

ABSTRACT: The flagellum in Trypanosoma brucei plays crucial roles in cell locomotion, cell morphogenesis, and cell division, and its inheritance depends on the faithful duplication of multiple flagellum-associated structures. One of such cytoskeletal structures is a hairpin-like structure termed the hook complex composed of a fishhook-like structure and a centrin arm structure, whose cellular functions remain poorly understood. We recently identified KIN-G, an orphan kinesin that promotes hook complex and Golgi biogenesis. Here we report a WD40 repeats-containing protein named WDR2, which interacts with and regulates KIN-G. WDR2 co-localizes with KIN-G at the centrin arm, and knockdown of WDR2 disrupts hook complex integrity and morphology, inhibits flagellum attachment zone elongation and fl

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC11838399 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature