A Quantitative Approach to Mapping Mitochondrial Specialization and Plasticity.

ABSTRACT: Mitochondria are a diverse family of organelles that specialize to accomplish complimentary functions ^1-3. All mitochondria share general features, but not all mitochondria are created equal⁴.Here we develop a quantitative pipeline to define the degree of molecular specialization among different mitochondrial phenotypes - or mitotypes. By distilling hundreds of validated mitochondrial genes/proteins into 149 biologically interpretable MitoPathway scores (MitoCarta 3.0 ⁵) the simple mitotyping pipeline allows investigators to quantify and interpret mitochondrial diversity and plasticity from transcriptomics data across a variety of natural and experimental contexts. We show that mouse and human multi-organ mitotypes segregate along two main axes of mi

SUBMITTER: Monzel AS 

PROVIDER: S-EPMC11838522 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature