Multivariate Neural Markers of Individual Differences in Thought Control Difficulties.

ABSTRACT: Difficulties in controlling thought, including pathological rumination, worry, and intrusive thoughts, occur in a range of mental health disorders. Here we identify specific patterns of brain activity distributed within and across canonical brain networks that are associated with self-reported difficulties in controlling one's thoughts. These activity patterns were derived using multivariate pattern analysis on fMRI data recorded while participants engaged in one of four operations on an item in working memory: maintaining it, replacing it with another, specifically suppressing it, or clearing the mind of all thought. Individuals who reported greater difficulties exhibited brain activation patterns that were more variable and less differentiated across the four operations in frontoparietal

SUBMITTER: DeRosa J 

PROVIDER: S-EPMC11838559 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature