INTERMUSCULAR ADIPOSE TISSUE AND MUSCLE FUNCTION IN PATIENTS ON MAINTENANCE HEMODIALYSIS.

ABSTRACT:

Background and aims

Sarcopenia, defined as a loss in muscle mass and strength, is common in patients with advanced chronic kidney disease (CKD), leading to poor outcomes. Intermuscular adipose tissue (IMAT) accumulation is associated with metabolic and functional abnormalities in chronic disease conditions. This study assesses IMAT in maintenance hemodialysis (MHD) patients and its association with metabolic markers and physical performance.

Methods and results

We performed a cross-sectional study comparing MHD patients with controls. IMAT accumulation was measured by analyzing the fat-to-muscle ratio of the calf muscles through Magnetic Resonance Imaging (MRI) scans. Body composition and metabolic markers were assessed (hs-CRP, TNF-α, IL-6, and insulin resistance). Circulat

SUBMITTER: Dilaver RG 

PROVIDER: S-EPMC11838629 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature