Circulating causal protein networks linked to future risk of myocardial infarction.

ABSTRACT: Variations in blood protein levels have been associated with a broad spectrum of complex diseases, including atherosclerotic cardiovascular disease (ACVD). These associations highlight the intricate interplay between local (e.g., cardiovascular) and systemic (non-cardiovascular) factors for the development of ACVD, emphasizing the need for a comprehensive, systems-level understanding of its etiology. To accomplish this, we developed a causal network inference framework by analyzing one of the largest serum proteomics studies to date, the Age, Gene/Environment Susceptibility-Reykjavik Study (AGES), a prospective population-based study of 7,523 serum proteins measured in 5,376 older adults. To reconstruct a causal network of serum proteins, we used cis-acting protein quantitative trai

SUBMITTER: Bankier S 

PROVIDER: S-EPMC11838656 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature