Balanced steady state free precession enables high-resolution dynamic 3D Deuterium Metabolic Imaging of the human brain at 7T.

ABSTRACT:

Objectives

Deuterium (²H) Metabolic Imaging (DMI) is an emerging magnetic resonance technique to non-invasively map human brain glucose (Glc) uptake and downstream metabolism following oral or intravenous administration of ²H-labeled Glc. The achievable spatial resolution is limited due to inherently low sensitivity of DMI. This hinders potential clinical translation. The purpose of this study was to improve the signal-to-noise ratio (SNR) of 3D DMI via a balanced steady state free precession (bSSFP) acquisition scheme combined with fast non-Cartesian spatial-spectral sampling to enable high resolution dynamic imaging of neural Glc uptake and glutamate+glutamine (Glx) synthesis of the human brain at 7T.

Materials and methods

Six healthy volunteers (2f/4

SUBMITTER: Frese S 

PROVIDER: S-EPMC11838661 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature