Vaccine Effectiveness Among 5- to 17-year-old Individuals with Prior SARS-CoV-2 Infection: An EHR-Based Target Trial Emulation Study from the RECOVER Project.

ABSTRACT:

Importance

Prior studies have demonstrated the effectiveness of COVID-19 vaccines in children and adolescents. However, the benefits of vaccination in these age groups with prior infection remain underexplored.

Objective

To evaluate the effectiveness of COVID-19 vaccination in preventing reinfection with various Omicron subvariants (BA.1/2, BA.4/5, XBB, and later) among 5- to 17-year-olds with prior SARS-CoV-2 infection.

Design

A target trial emulation through nested designs with distinct study periods.

Setting

The study utilized data from the Research COVID to Enhance Recovery (RECOVER) initiative, a national electronic health record (EHR) database comprising 37 U.S. children's hospitals and health institutions.

Participants

Individuals aged 5-17 years

SUBMITTER: Chen J 

PROVIDER: S-EPMC11838676 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature