Bile acid dysmetabolism in Bangladeshi infants is associated with poor linear growth, enteric inflammation, and small intestine bacterial overgrowth.

ABSTRACT:

Introduction

Environmental enteric dysfunction (EED) is a subclinical condition caused by fecal-oral contamination leading to enteric inflammation and dysbiosis. This study investigates bile acid metabolism in Bangladeshi children with EED and its association with growth impairment.

Methods

We conducted a cross sectional study of 100 Bangladeshi infants (aged 6-9 months) and quantified serum and fecal bile acids using LC-MS/MS. We compared profiles to a control group of 6 American children (6 - 12 months) and 80 older Bangladeshi children (aged 2 years).

Results

Bangladeshi infants had higher levels of plasma unconjugated primary (65.23% vs. 44.25%, p = .003) and sulfated primary bile acids (12.98% vs. <0.001%, p = .01), with lower primary conjugated bile acids (0.69%

SUBMITTER: Hasan F 

PROVIDER: S-EPMC11838691 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature