Epigenome-wide association study of cerebrospinal fluid-based biomarkers of Alzheimer's disease in cognitively normal individuals.

ABSTRACT:

Introduction

Cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) are reliable predictors of future AD risk. We investigated whether pre-clinical changes in AD CSF biomarkers are reflected in blood DNA methylation (DNAm) levels in cognitively normal participants.

Methods

We profiled blood-based DNAm with the EPIC array in participants without a diagnosis of cognitive impairment in the Emory Healthy Brain Study (EHBS; N=495) and ADNI (N=122). Their CSF Aβ42, tTau, and pTau levels were quantified using Elecsys immunoassays. We conducted epigenome-wide association studies to assess associations between DNAm and CSF biomarkers of AD.

Results

In EHBS, no loci were Bonferroni-significant after adjusting for confounding factors. In ADNI, two loci were significant

SUBMITTER: Huls A 

PROVIDER: S-EPMC11838696 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature