A ketogenic diet enhances aerobic exercise adaptation and promotes muscle mitochondrial remodeling in hyperglycemic mice.

ABSTRACT: VO₂peak is a key health benefit of aerobic exercise; however, chronic hyperglycemia is associated with persistently low VO₂peak due to an impaired adaptive response to training. Here, we tested whether reducing blood glucose with a low-carbohydrate/high-fat "ketogenic" diet could restore aerobic exercise adaptation in a mouse model of hyperglycemia. Hyperglycemia was induced by streptozotocin (STZ) and mice were stratified to standard chow (STZ-CHOW), or a ketogenic diet (STZ-KETO), which rapidly normalized blood glucose. After aerobic exercise training, improvements in VO₂peak were blunted in STZ-CHOW, but exercise response was restored in STZ-KETO. Improved VO₂peak in STZ-KETO was associated with enhanced aerobic remodeling of skeletal muscle,

SUBMITTER: Pattamaprapanont P 

PROVIDER: S-EPMC11838742 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature