Loss of Cutibacterium is responsible for chronic kidney disease-associated pruritus in patients on dialysis.

ABSTRACT:

Background

Chronic kidney disease (CKD)-associated pruritus is a severe distressing condition that frequently occurs in patients undergoing dialysis. In this study, the profile of the skin microbiome was analyzed to understand the underlying etiology and potential treatments.

Methods

Seventy-six end-stage kidney disease (ESKD) patients (hemodialysis, 40; peritoneal dialysis, 36) and 15 healthy controls were enrolled and swabbed at three sites: back, antecubital fossa, and shin. The pruritus severity of the enrolled subjects was validated by the Worst Itch Numeric Rating Scale (WI-NRS), 5-D itch scale, and Uremic Pruritus in Dialysis Patients (UP-Dial). The 16S genebased metagenomics method was applied to skin microbiome analysis.

Results

In the comparison of bacterial

SUBMITTER: Lee JG 

PROVIDER: S-EPMC11838852 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature