Sex Differences in Endocannabinoid and Inflammatory Markers Associated with Posttraumatic Stress Disorder.

ABSTRACT:

Background

Posttraumatic stress disorder (PTSD) is one of the most sex-polarized psychiatric disorders, with women exhibiting twice the prevalence of men. The biological mechanisms underlying this sex disparity are not fully understood. Growing evidence suggests that alterations of the stress-buffering endocannabinoid (eCB) system and heightened inflammation are central to PTSD pathophysiology and may contribute to sex-biases in PTSD risk and severity. Here, we examined sex-differences in levels of circulating eCBs and peripheral pro-inflammatory markers in a cohort of men and women with PTSD and non-psychiatric controls.

Methods

88 individuals with PTSD and 85 sex- and age- matched controls (HC) were retrospectively selected from the Mass General Brigham Biobank. Serum was

SUBMITTER: Rajasekera TA 

PROVIDER: S-EPMC11838936 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature