Distress is positively associated with induced secondary hyperalgesia in people with suppressed HIV.

ABSTRACT: Pain and distress are frequently reported by people with HIV. Although pain is widely acknowledged to contribute to distress, distress may also contribute to pain and its persistence. Facilitation of nociceptive signalling in the spinal dorsal horn is one pathway by which distress could exacerbate pain. The current study investigated the relationships between distress, secondary hyperalgesia (SH), and persistent pain in people with HIV, reporting pain (n=19) or no pain (n=26). We hypothesised that self-reported distress would be positively associated with the surface area (primary measure) and magnitude (secondary measure) of induced SH, and that participants reporting persistent pain would display greater induced SH than those reporting no pain. We found that distress was positively assoc

SUBMITTER: Mqadi L 

PROVIDER: S-EPMC11838949 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature