Homologous recombination deficiency in ovarian high-grade serous carcinoma by self-reported race.

ABSTRACT:

Background

Approximately half of ovarian high-grade serous carcinomas (HGSC) have homologous recombination deficiency (HRD). However, HRD is not well-characterized in Black individuals.

Objective

To characterize HGSC HRD by self-reported race and evaluate whether differences in HRD are associated with ovarian cancer mortality.

Study population

Cohort study using data collected from two population-based case-control studies of ovarian cancer. Cases were selected based on self-reported race (178 Black, 123 White) and pathologically-confirmed HGSC.

Exposures

HRD features identified using matched tumor-normal whole-exome DNA sequencing and categorized as germline or somatic variants in homologous recombination pathway genes, or the SBS3 HRD-associated signature.

SUBMITTER: Lawson-Michod KA 

PROVIDER: S-EPMC11838950 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature