Understanding Telomere Biology in Hematopoietic Cell Transplantation: A Dynamical Systems Perspective.

ABSTRACT:

Background

T cell proliferation and repertoire reconstitution is a hallmark of successful hematopoietic cell transplantation (HCT). This process may be modeled as a dynamical system and in such a system, precise telomere length (TL) measurement may reflect the proliferative capacity of donor T cells. TL for different chromosomes span a few orders of magnitude, and different T cell clones will display variable TL; these differences across the population are not represented when examining average TL. This study aims to develop a method that integrates the entire spectrum of TL observed within a sample to better understand the influence on clinical outcomes following HCT.

Methods

To better reflect the entire span of TL, we used data generated using the TeLSA PCR technique that

SUBMITTER: Toor AA 

PROVIDER: S-EPMC11838954 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature