Distinct clinical phenotypes and their neuroanatomic correlates in chronic traumatic brain injury.

ABSTRACT: Accumulating evidence of heterogeneous long-term outcomes after traumatic brain injury (TBI) has challenged longstanding approaches to TBI outcome classification that are largely based on global functioning. A lack of studies with clinical and biomarker data from individuals living with chronic (>1 year post-injury) TBI has precluded refinement of long-term outcome classification ontology. Multimodal data in well-characterized TBI cohorts is required to understand the clinical phenotypes and biological underpinnings of persistent symptoms in the chronic phase of TBI. The present cross-sectional study leveraged data from 281 participants with chronic complicated mild-to-severe TBI in the Late Effects of Traumatic Brain Injury (LETBI) Study. Our primary objective was to develop and validate

SUBMITTER: Kumar RG 

PROVIDER: S-EPMC11838966 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature