Treatment outcomes of bedaquiline-resistant tuberculosis: a retrospective and matched cohort study.

ABSTRACT:

Background

Rising prevalence of bedaquiline resistance undermines benefits from this life-saving drug for rifampicin-resistant tuberculosis (RR-TB). Despite increasing awareness, patient-level outcomes for bedaquiline-resistant TB have not been well-characterised and case management poorly defined.

Methods

We conducted a retrospective cohort study with matched controls at a TB referral hospital in South Africa. Cases included patients ≥13 years with a phenotypic bedaquiline-resistant Mycobacterium tuberculosis isolate identified between January 2018 and June 2023. Matched controls (1:1) with bedaquiline-susceptible RR-TB were selected from a prospective observational study conducted at the same facility. Primary outcomes included time to sputum culture conversion (SCC

SUBMITTER: Mdlenyani L 

PROVIDER: S-EPMC11838984 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature