The association of umbilical cord blood neurofilament light with non-reassuring fetal status: a prospective observational study.

ABSTRACT:

Objective

Early detection of hypoxic-ischaemic encephalopathy (HIE) in neonates is critical. We conducted a pilot cohort study to determine the feasibility of collecting umbilical cord blood samples for neurofilament light (NfL) and to assess the association of NfL with non-reassuring fetal status and other cord biomarkers.

Design

Prospective cohort study.

Setting

A single, large tertiary and quaternary referral hospital.

Patients

108 maternal participants consenting to donate cord blood.

Intervention

Umbilical cord venous blood plasma NfL levels.

Main outcome measures

(1) Feasibility of cord NfL sample collection and analysis; (2) Association of NfL with non-reassuring fetal status (CTG changes and/or documented non-reassuring fetal status), NICU

SUBMITTER: Zalcberg D 

PROVIDER: S-EPMC11838990 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature