Implications of successive blood feeding on <i>Wolbachia</i>-mediated dengue virus inhibition in <i>Aedes aegypti</i> mosquitoes.

ABSTRACT: Dengue virus (DENV) is a mosquito-borne virus that poses a continued and increasing threat to public health. A promising strategy to mitigate the burden of DENV is introgression of the virus-inhibiting Wolbachia pipientis bacterium into Aedes aegypti populations in the field. While previous studies on Wolbachia-mediated virus inhibition have typically assessed viral replication following a single bloodmeal, the main vector of DENV, Ae. aegypti, feeds frequently, often biting multiple hosts per gonotrophic cycle and promptly attempting to refeed following egg laying. Previously, we demonstrated that successive blood feeding reduces the extrinsic incubation period (EIP) and shortens the time it takes for a mosquito to be able to transmit viruses to a new host. Wit

SUBMITTER: Johnson RM 

PROVIDER: S-EPMC11839047 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature