Methodologic Approach to Defining Comorbidities in a Cohort of Patients With Cancer: An Example in the Optimal Breast Cancer Chemotherapy Dosing Study.

ABSTRACT:

Purpose

We evaluated the definitions of five comorbidities (renal and hepatic impairments, anemia, neutropenia, and thrombocytopenia) in women with breast cancer using data from electronic health records.

Methods

In 11,097 women receiving adjuvant chemotherapy for stage I-IIIA breast cancer at Kaiser Permanente Northern California or Kaiser Permanente Washington, we assessed comorbidity definitions in two commonly used lookback windows (1 year before diagnosis, T1; and extending until chemotherapy initiation, T1-2). Within each, we assessed data availability and agreement between International Classification of Diseases (ICD)-defined and lab-defined comorbidities of varying severity. To assess how different pieces of information may affect providers in making treatment decis

SUBMITTER: Wang P 

PROVIDER: S-EPMC11839177 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature