Glial cell line derived neurotrophic factor (GDNF) induces mucosal healing via intestinal stem cell niche activation.

ABSTRACT: Mucosal healing is critical to maintain and restore intestinal homeostasis in inflammation. Previous data provide evidence that glial cell line-derived neurotrophic factor (GDNF) restores epithelial integrity by largely undefined mechanisms. Here, we assessed the role of GDNF for mucosal healing. In dextran sodium sulphate (DSS)-induced colitis in mice application of GDNF enhanced recovery as revealed by reduced disease activity index and histological inflammation scores. In biopsy-based wounding experiments GDNF application in mice improved healing of the intestinal mucosa. GDNF-induced epithelial recovery was also evident in wound assays from intestinal organoids and Caco2 cells. These observations were accompanied by an increased number of Ki67-positive cells in vivo after GDNF treatmen

SUBMITTER: Horner M 

PROVIDER: S-EPMC11839185 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature