Human Brain Organoids Model Abnormal Prenatal Neural Development Induced by Thermal Stimulation.

ABSTRACT: The developing human foetal brain is sensitive to thermal stimulation during pregnancy. However, the mechanisms by which heat exposure affects human foetal brain development remain unclear, largely due to the lack of appropriate research models for studying thermal stimulation. To address this, we have developed a periodic heating model based on brain organoids derived from human pluripotent stem cells. The model recapitulated neurodevelopmental disruptions under prenatal heat exposure at the early stages, providing a paradigm for studying the altered neurodevelopment under environmental stimulation. Our study found that periodic heat exposure led to decreased size and impaired neural tube development in the brain organoids. Bulk RNA-seq analysis revealed that the abnormal WNT signalling p

SUBMITTER: Xu L 

PROVIDER: S-EPMC11839188 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature