Maternal infection with SARS-CoV-2 during early pregnancy induces hypoxia at the maternal-fetal interface.

ABSTRACT: The coronavirus disease 2019 (COVID-19) pandemic increases the risk of adverse fetal outcomes during pregnancy. Maternal infection during pregnancy, particularly with cytomegalovirus (CMV), hepatitis B and C virus, and human immunodeficiency virus can have detrimental effects on both mother and fetus, potentially leading to adverse outcomes such as spontaneous abortion or neonatal infection. However, the impact of severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection on the maternal-fetal interface remains poorly understood. In this study, we initially utilised immunofluorescence and immunohistochemical to investigate placental samples from pregnant women who were infected with SARS-CoV-2 during the first trimester. Our data indicate that infection in the first trimester ind

SUBMITTER: Shi X 

PROVIDER: S-EPMC11839197 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature