Associations between sleep traits and colorectal cancer: a mendelian randomization analysis.

ABSTRACT:

Background

Although many researches have shown a relationship between sleeping habits and the risk of developing colorectal cancer (CRC), there is a lack of data from randomized controlled trials (RCTs) to support this point. Hence, this study used Mendelian randomization (MR) to robustly assess whether five primary sleep characteristics are directly linked with the risk of CRC occurrence.

Methods

In the performed study, the main Mendelian randomization analysis was conducted using approaches such as Inverse Variance Weighting (IVW), MR Egger, and weighted median method. To this end, five genetically independent variants associated with the sleep-related characteristics (chronotype, sleep duration, insomnia, daytime napping, and daytime fatigue) were identified and used as i

SUBMITTER: Meng X 

PROVIDER: S-EPMC11839420 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature