Systematic identification of cancer pathways and potential drugs for intervention through multi-omics analysis.

ABSTRACT: The pathogenesis of cancer is complicated, and different types of cancer often exhibit different gene mutations resulting in different omics profiles. The purpose of this study was to systematically identify cancer-specific biological pathways and potential cancer-targeting drugs. We collectively analyzed the transcriptomics and proteomics data from 16 common types of human cancer to study the mechanism of carcinogenesis and seek potential treatment. Statistical approaches were applied to identify significant molecular targets and pathways related to each cancer type. Potential anti-cancer drugs were subsequently retrieved that can target these pathways. The number of significant pathways linked to each cancer type ranged from four (stomach cancer) to 112 (acute myeloid leukemia), and the

SUBMITTER: Xu T 

PROVIDER: S-EPMC11839471 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature