Family study of bipolar disorder with comorbid anxiety disorder points to THSD7A with possible role of parent-of-origin effect.

ABSTRACT:

Aim

The aim of this study was to provide new insights into the genetics of bipolar disorder (BD) by analyzing BD comorbid with anxiety disorders.

Methods

Structured interviews were conducted with BD patients and their parents. Cases were classified into those with comorbid anxiety spectrum (AS) and those without. The family history of patients with BD with comorbid AS was assessed. Focusing on parent-of-origin effects and genomic imprinting from the results, imprinted genes and tested single nucleotide polymorphisms (SNPs) in the identified genes were investigated for an association with BD by transmission disequilibrium test (TDT) using published whole-exome sequencing data.

Results

The incidence of comorbid AS among all the patients with BD analyzed in this study wa

SUBMITTER: Maki H 

PROVIDER: S-EPMC11839488 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature