Accelerated structural valve deterioration in systemic sclerosis patients following transcatheter aortic valve replacement: a case series.

ABSTRACT:

Background

Systemic sclerosis (SSc) is marked by an excessive systemic accumulation of collagen. Recent literature implies that aortic stenosis is more prevalent in patients with SSc than previously thought. While there are limited feasibility studies on transcatheter aortic valve replacement (TAVR) in this population, the long-term outcomes remain uncertain.

Case summary

We report two cases of patients with SSc who developed early structural valve deterioration following TAVR, necessitating successful redo-TAVR procedures. Both patients exhibited extensive soft tissue calcinosis as a manifestation of their underlying condition.

Discussion

The fibrotic and calcific processes inherent to certain SSc subtypes could potentially adversely impact the durability and functio

SUBMITTER: Avidan Y 

PROVIDER: S-EPMC11839506 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature