Causal Relationship Between Inflammatory Cytokines and Pancreatitis Risk.

ABSTRACT: The causal relationship between inflammatory factors and acute pancreatitis (AP), chronic pancreatitis (CP), alcohol-induced acute pancreatitis (AAP), and alcohol-induced chronic pancreatitis (ACP) remains unclear. We aimed to examine the casual relationship between inflammatory factors and various forms of pancreatitis, namely, AP, CP, AAP, and ACP. We employed a two-sample Mendelian randomization (MR) analysis to investigate the causal relationship between 91 inflammatory factors and 41 inflammatory factors with respect to pancreatitis. The primary analysis involved the use of the inverse variance weighting (IVW). MR-Egger intercept test, Cochran's Q test, MR-PRESSO test, and Leave-One-Out analysis were used to assess the robustness of our findings. IVW analysis revealed evidence

SUBMITTER: Yu H 

PROVIDER: S-EPMC11839544 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature