Genetically predicted vitamins supplementation and risk of skin cancers: a Mendelian randomization study.

ABSTRACT:

Background

The causal relationship between vitamins supplementation and the risk of skin cancers remains unclear. We conducted a Mendelian randomization study to assess the associations between vitamins supplementation and skin cancers in the general population.

Objective

We aimed to investigate the causal relationship of vitamins (A-E) supplementation with skin cancers using and utilizing the linkage disequilibrium score regression (LDSC) Mendelian randomization (MR).

Materials and methods

We selected genome-wide significant single-nucleotide polymorphisms (SNPs) linked to vitamin supplements (A-E). Summary-level data for melanoma, basal cell carcinoma, and squamous cell carcinoma were obtained from large-scale genome-wide association studies. We applied the inverse-

SUBMITTER: Qi P 

PROVIDER: S-EPMC11839550 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature