Exploring modifiable risk factors: insights from Mendelian randomization analyses of gastric cancer in East Asian populations.

ABSTRACT:

Background

The incidence of gastric cancer (GC) shows strong geographic variation, with the highest incidence occurring in East Asia. Epidemiological studies have linked lifestyle, diet, and inflammatory factors to the risk of GC. However, their causal relationship is subject to debate due to the potential presence of bias. Addressing these uncertainties is vital for guiding effective preventive strategies.

Methods

We used genetic variants as instruments via two-sample univariate and multivariate Mendelian randomization analyses to examine the relationships between 40 potentially modifiable risk factors and gastric cancer in 6563 patients with gastric cancer and 195,745 controls. These population data came from a genome-wide association study of people of Asian ancestry and

SUBMITTER: He W 

PROVIDER: S-EPMC11839552 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature