BAFF and APRIL immunotherapy following Bacille Calmette-Guerin vaccination enhances protection against pulmonary tuberculosis in mice.

ABSTRACT:

Introduction

Bacille Calmette-Guérin (BCG), the only tuberculosis vaccine currently in clinical use, provides inadequate long-term protection. Administered at birth, BCG induces broad immune responses against a large number of antigens shared with Mycobacterium tuberculosis (Mtb), but protection wanes over time. We have previously shown that unconventional B cell subsets play a role in tuberculosis control.

Methods

High-dimensional flow cytometry and multiplex cytokine analysis were employed to investigate the effects of immunotherapy on BCG-vaccinated mice in an Mtb challenge model.

Results

In this study, we investigate the potential of recombinant cytokines targeting B cells - B-cell activating factor (BAFF) and A proliferation-inducing ligand (APRIL) - to mo

SUBMITTER: Xie M 

PROVIDER: S-EPMC11839638 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature