Three-dimensional amide proton transfer (APT) imaging appliable to navigation surgery can present comparable metabolic activity of glioblastoma to ¹¹C-Methionine PET.

ABSTRACT:

Background

Amide proton transfer (APT) imaging has been proposed as a technique to assess tumor metabolic activity. We have previously ¹¹C-methionine positron emission tomography (¹¹C-Met-PET) can evaluate the metabolic activity of peritumoral area including infiltrating tumor cells in glioblastoma (GBM). To resolve disadvantages of ¹¹C-Met-PET, in the present study, we aimed to evaluate whether three-dimensional fast spin echo-based APT (3D FSE-APT) imaging is usable for not only presenting the metabolic activity of brain tumors, but also detecting areas where infiltrating tumor cells including glioma stem cells (GSCs) could exist, by applying an image-guided navigation system incorporating 3D FSE-APT to glioblastoma surgery.

Methods

Twenty-

SUBMITTER: Inoue A 

PROVIDER: S-EPMC11839683 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature