Mendelian Randomization and Colocalization Analysis Reveal New Drug Targets for Oral Ulcer: A Mendelian Randomization Analysis.

ABSTRACT:

Background and aims

Oral ulcer (OU) is a complex issue with limited effective treatments. This study uses multi-omics data through summary Mendelian randomization (SMR) and colocalization analysis to identify specific gene associations with OU, aiming to find new therapeutic targets, repurpose existing drugs, and develop new treatment options.

Methods

Our study consists of two phases: first, extracting data from Genome-Wide Association Studies and using blood mQTL, eQTL, and pQTL data as exposure factors, then integrating these with OU gene data through SMR analysis. Then, we validate the results with UK Biobank data and perform colocalization analysis to confirm shared genetic variants.

Results

Genetically predicted levels of four circulating proteins are associated

SUBMITTER: Zhang X 

PROVIDER: S-EPMC11839742 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature